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Tadalafil
From: £8.99
Or £8.09 / month
Cialis is the original branded tadalafil, manufactured by Eli Lilly. It can remain effective for up to 36 hours from a single dose. Available on-demand (10mg/20mg) or as a daily dose (2.5mg/5mg). Clinically equivalent to generic Tadalafil — preferred by men who want the original brand.
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Additional information
| Strength | 10mg, 20mg, 5mg |
|---|---|
| Quantity | 16, 20, 24, 28, 32, 4, 56, 8, 84 |
Overview
Content Written by:
Hanifa Tai
Hanifa Tai
Role: Pharmacist & Content Writer
GPhC Number: 2074961
Content Published: 01/04/2026
Next Review: 01/04/2027
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Description
What Is Cialis?
Cialis is the original long-acting branded ED treatment containing tadalafil, manufactured by Eli Lilly. It is well known for its extended 36-hour duration of action. Available as 10mg and 20mg on-demand tablets, and 2.5mg and 5mg daily tablets. Sexual arousal is required — Cialis does not cause a spontaneous erection.
How Does It Work?
During sexual stimulation, nitric oxide is released in penile tissue, triggering cyclic GMP production. This relaxes smooth muscle and widens blood vessels. Tadalafil temporarily inhibits the PDE5 enzyme that breaks down cyclic GMP, supporting erection quality. Tadalafil’s longer half-life compared to sildenafil explains its extended 36-hour window.
On-Demand vs Daily Cialis
On-demand Cialis (10mg/20mg): taken at least 30 minutes before activity, effective for up to 36 hours. Daily Cialis (2.5mg/5mg): taken at the same time each day, providing continuous coverage and removing the need to plan around a tablet. Daily Cialis is also licensed for benign prostatic hyperplasia (BPH) where it may improve urinary symptoms.
Cialis vs Generic Tadalafil
Cialis contains tadalafil as its active ingredient. Generic tadalafil contains the same active ingredient at equivalent strengths. From a clinical perspective, they are considered equivalent in safety and effectiveness when sourced from regulated UK pharmacies. Differences relate to branding, manufacturer, packaging and cost. Cialis is produced by Eli Lilly.
Is Cialis Better Than Sildenafil?
Both are highly effective. The primary difference is duration: Sildenafil typically works for 4–6 hours, while Cialis may remain effective for up to 36 hours. Cialis is also less affected by food intake. Choice often depends on lifestyle preference and individual response.
FAQ
Q: How long does Cialis last?
A: After an on-demand dose, Cialis may remain effective for up to 36 hours. This does not mean a constant erection — it means the body remains more responsive to sexual stimulation during that window.
Q: How quickly does Cialis work?
A: Cialis can begin working within 30 minutes for some men, though optimal effect may take up to 2 hours. Because of its long duration, exact timing is less critical than with shorter-acting treatments.
Q: Can Cialis be taken with food?
A: Yes. Food does not significantly affect Cialis absorption, which adds to its convenience.
Q: What is the difference between Cialis and Cialis 10mg Together?
A: Both contain tadalafil. Cialis 10mg Together is a specific branded pack of the 10mg strength, commonly used as a starting on-demand dose. Both work in the same way and have the same 36-hour duration profile.
Q: Is Cialis suitable if I have prostate problems?
A: Yes. Daily Cialis 5mg is also licensed for benign prostatic hyperplasia (BPH) and may improve urinary symptoms alongside ED treatment.
Side Effects
Common Side Effects
These are usually mild and resolve as the medicine leaves the body:
- Headache
- Flushing
- Nasal congestion
- Indigestion
- Back pain
- Muscle aches (usually resolve within 48 hours)
Rare but Serious Side Effects — Seek Urgent Medical Attention
- Chest pain — seek urgent medical help
- Sudden loss of vision — seek urgent medical help
- Sudden hearing loss — seek urgent medical help
- Erection lasting longer than 4 hours (priapism) — seek urgent medical help
Do Not Take If You:
- Use nitrates or nitric oxide donors
- Have been advised to avoid sexual activity for cardiac reasons
- Have severe low blood pressure
- Have recently experienced a heart attack or stroke
- Have certain rare inherited eye disorders
Cardiovascular Note: Sexual activity places moderate physical strain on the cardiovascular system. If you can climb two flights of stairs without chest pain or severe breathlessness, sexual activity is generally considered safe. Men with unstable heart disease should be assessed before treatment.
